| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject ester useful as an important intermediate for pharmaceuticals and agrochemicals in high efficiency by converting a diol compound into an orthoester compound and opening the ring with a sulfonic acid. SOLUTION: The objective acyloxysulfonic acid ester of the formula III can be produced by reacting a 1,2-diol compound of the formula I (X is H, a non-substituted or phenyl-substituted 1-4C alkyl, a halogen, cyano, etc.) with an orthoester in the presence of an acid catalyst and reacting the resultant orthoester compound of the formula II (R3 is H, a 1-4C alkyl or a non- substituted or 1-4C alkyl-substituted phenyl; R4 is a 1-4C alkyl) with a sulfonic acid of the formula R1 SO3 H (R1 is a 1-4C alkyl, nonsubstituted phenyl or a phenyl having substituent selected from a 1-4C alkyl, nitro and a halogen). The process enables the simultaneous introduction of a sulfonate group to the 1-site and an ester group to the 2-site of a 1,2-diol compound in one pot. |
