| 摘要 |
PCT No. PCT/US93/12419 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Dec. 17, 1993 PCT Pub. No. WO94/14833 PCT Pub. Date Jul. 7, 1994 <IMAGE> (I) The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R1 and R2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R1 and R2 is a single bond; R3 is preferably hydrogen, halogen or lower alkyl, R4 is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR14R15 and R14 and R15 are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.
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