Erythromycins, particularly with C-13 substituents R1 (e.g. C3-C6 cycloalkyl or cycloalkenyl groups) are prepared by fermenting suitable organisms in the presence of R1CO2H. A preferred organism is Saccharopolyspora erythraea preferably containing an integrated plasmid capable of directing synthesis of desired compounds.
申请公布号
WO9801571(A2)
申请公布日期
1998.01.15
申请号
WO1997GB01810
申请日期
1997.07.04
申请人
BIOTICA TECHNOLOGY LIMITED;PFIZER INC.;LEADLAY, PETER, FRANCIS;STAUNTON, JAMES;CORTES, JESUS;PACEY, MICHAEL, STEPHEN
发明人
LEADLAY, PETER, FRANCIS;STAUNTON, JAMES;CORTES, JESUS;PACEY, MICHAEL, STEPHEN