发明名称 |
Antiproliferative quinazolines |
摘要 |
Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
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申请公布号 |
US5707992(A) |
申请公布日期 |
1998.01.13 |
申请号 |
US19950418415 |
申请日期 |
1995.04.07 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
WEBBER, STEPHEN E.;BLECKMAN, TED M.;ATTARD, JOHN;JONES, TERENCE R.;VARNEY, MICHAEL D. |
分类号 |
A61K31/505;A61K31/517;A61P31/04;A61P31/10;A61P35/00;C07D239/88;C07D239/90;C07D239/91;C07D239/93;C07D239/95;C07D401/06;C07D401/12;C07D403/06;C07D403/12;C07D417/12;(IPC1-7):A61K31/505 |
主分类号 |
A61K31/505 |
代理机构 |
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地址 |
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