摘要 |
PROBLEM TO BE SOLVED: To obtain the subject composition capable of increasing solubility and directly obtaining an aqueous solution in a neutral area by adding calcium chloride, etc., to a specific pyrrolidone carboxylic acid. SOLUTION: This aqueous composition is obtained by adding (B) a calcium salt (e.g. calcium chloride) and (C) polyvinylpyrrolidone to (A) a pyrrolidone carboxylic acid of formula I or formula II [R1 is a 1-5C alkyl, a 3-6C cycloalkyl, 2,4-difluorophenyl, etc.; R2 is H, a halogen or an amino; R3 is an amino, a 1-5C aminoalkyl, an alkyalmino, alkyl, etc.; A is NCH, etc.; R4 is H or a 1-5C alkyl; B is O or S; X is H r a halogen] which is an amphoteric compound and has antimicrobial activity r its salt and controlling the mixture to pH6.0 to 8.5. Furthermore, e.g. (±)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthylidine-3-carboxylic acid paratoluenesulfonate hydrate is preferably used as the component A.
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