Preparation of 4,6-di:hydroxy-pyrimidine, useful as intermediate for fungicides - by reaction of a malonic acid ester with formamide and an alkali metal alkoxide

摘要

Preparation of 4,6-dihydroxypyrimidine (DHP) by reaction of a malonic acid ester with formamide and an alkali metal alkoxide at elevated temperature. The ester (optionally with all or part of the formamide) is added portionwise or continuously to an alcoholic solution or suspension of the alkoxide (which may optionally contain all or the remaining part of the formamide).