发明名称 |
CAPSID POLYPEPTIDES AND USE TO INHIBIT VIRAL PACKAGING |
摘要 |
The present invention is directed to a viral capsid polypeptide capable of inhibiting viral packaging, the viral capsid polypeptide consisting of a portion of a viral capsid protein of an RNA virus and including a multimerization domain of the viral capsid protein. The invention further provides an isolated nucleic acid molecule encoding such a viral capsid polypeptide. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as a method for inhibiting viral packaging in a host cell by expressing the viral capsid polypeptide. In two preferred embodiments, the RNA virus is the ScVL1 virus or the ScVLa virus of Saccharomyces cerevisiae.
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申请公布号 |
WO9800525(A1) |
申请公布日期 |
1998.01.08 |
申请号 |
WO1997US11216 |
申请日期 |
1997.06.26 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW |
发明人 |
BRUENN, JEREMY, A.;YAO, WENSHENG |
分类号 |
A61K38/00;C07K14/08;(IPC1-7):C12N7/04;C12N15/00;C12N15/09;C12N15/11;C12N15/33;C12N15/34;C07K14/005 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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