It is one object of the present invention to provide an oligonucleotide of formula (1): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside, wherein the oligonucleotide comprises at least one modified nucleotide dimer comprising two nucleoside analogs connected via an amide-bond that has a certain configuration; the synthesis of these compounds and their use in pharmaceutical preparations.
申请公布号
WO9800434(A1)
申请公布日期
1998.01.08
申请号
WO1997EP03192
申请日期
1997.06.19
申请人
NOVARTIS AG;DE MESMAEKER, ALAIN;WENDEBORN, SEBASTIAN;LEBRETON, JACQUES
发明人
DE MESMAEKER, ALAIN;WENDEBORN, SEBASTIAN;LEBRETON, JACQUES