METHODS AND COMPOSITIONS FOR SEQUENCE-SPECIFIC HYBRIDIZATION OF RNA BY 2'-5' OLIGONUCLEOTIDES

摘要

A 2'-5' oligonucleotide is hybridized to complementary nucleic acid which may be RNA or duplex DNA. The 2'-5' oligonucleotide is a methylphosphonate, a phosphorothioate or, especially preferred, a phosphodiester.