STABLE DRUG FORM FOR ORAL ADMINISTRATION WITH BENZIMIDAZOLE DERIVATIVES AS ACTIVE INGREDIENT AND PROCESS FOR THE PREPARATION THEREOF

摘要

The invention relates to a stable drug form which is for oral administration and comprises: (a) a centre comprising an active ingredient selected from omeprazole, lansoprazole and pantoprazole, together with conventional auxiliary pharmaceutical ingredients, (b) an intermediate layer applied to the centre, and (c) an external layer which is resistant to gastric juice. The intermediate layer in (b) is in the form of a reactive layer comprising a polymeric layered material which is partly neutralised with alkalis, is resistant to gastric juice and has cation-exchange capacity. A process for the preparation of the stable drug form is also disclosed.