发明名称 |
THIAZOLE DERIVATIVES |
摘要 |
<p>The present invention relates to a thiazole derivative represented by formula (I) <CHEM> wherein Ar<1> represents a substituted or unsubstituted phenyl or thienyl group, Y<1> and Y<2> are different and each represents a nitrogen atom or a sulfur atom, R<1> represents a hydrogen atom, a C1 to C5 alkyl group, a phenyl group, or an amino group unsubstituted or mono- or di-substituted with a C1 to C5 alkyl group, and R<2> represents a substituted or unsubstituted nitrogen heterocycle group, or a pharmaceutically acceptable salt thereof. The compound of the present invention are a dopamine D4 receptor antagonist which has an antipsychotic effect without causing any extrapyramidal disorder.</p> |
申请公布号 |
EP0816362(A1) |
申请公布日期 |
1998.01.07 |
申请号 |
EP19960906932 |
申请日期 |
1996.03.22 |
申请人 |
TAISHO PHARMACEUTICAL CO. LTD;NIHON NOHYAKU CO., LTD. |
发明人 |
NAKAZATO, ATSURO;KUMAGAI, TOSHIHITO;CHAKI, SHIGEYUKI;TOMISAWA, KAZUYUKI;NAGAMINE, MASASHI;GOTOH, MAKOTO;YOSHIDA, MASANORI |
分类号 |
C07D211/70;C07D277/22;C07D277/24;C07D277/40;C07D405/04;C07D417/04;C07D417/06;C07D417/14;(IPC1-7):C07D417/04;A61K31/425;A61K31/445;A61K31/495 |
主分类号 |
C07D211/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|