发明名称 Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
摘要 The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
申请公布号 AU3406197(A) 申请公布日期 1998.01.07
申请号 AU19970034061 申请日期 1997.06.19
申请人 REGENERON PHARMACEUTICALS, INC. 发明人 DAVID M VALENZUELA;PAMELA F JONES;GEORGE D YANCOPOULOS
分类号 C12N15/09;A61K38/00;A61K38/18;A61K45/00;A61K51/00;A61P35/00;C07K14/17;C07K14/47;C07K14/515;C07K14/71;C07K14/745;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/85;C12P21/02;C12P21/08 主分类号 C12N15/09
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