Method of reducing irritativeness of surface active agents and aqueous compositions with reduced irritativeness

摘要

A method to substantially eliminate irritativeness caused by surface active agents contained in an aqueous composition is provided. The method employs, in the production of said composition, in combination one or more surface active agents having an anionic active group with one or more nonionic surface active agents, with a mutual ratio of said one or more surface active agents having an anionic active group to said one or more nonionic surface active agents being 1:1 to 1:6 in concentration by weight. Aqueous compositions with reduced irritativeness as well as a method of solubilization of an insoluble or scarcely soluble pharmaceutical ingredient in producing an external-use aqueous pharmaceutical preparation are also provided.