发明名称 |
Use of substrate subtraction libraries to distinguish enzyme specificities |
摘要 |
The invention provides substrate substraction libraries and methods of using substrate substraction libraries to identify highly selective substrates for enzymes which use peptides as substrates. In one embodiment, substrates for proteases such as t-PA and u-PA have been identified whose relative reactivities towards the two enzymes vary by a factor of more than 9000. The substrates identified by the present invention are useful for the construction of highly selective enzyme inhibitors. |
申请公布号 |
AU3302497(A) |
申请公布日期 |
1998.01.07 |
申请号 |
AU19970033024 |
申请日期 |
1997.06.10 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
EDWIN L. MADISON;SONG-HUA KE |
分类号 |
C07K1/04;C07K14/81;C12N15/10;C40B40/02 |
主分类号 |
C07K1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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