Benzothiophene compounds, intermediates, processes, and methods of use

摘要

The instant invention provides novel benzothiophene compounds of the formula <CHEM> wherein: R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-CO-O-Ar in which Ar is optionally substituted phenyl, or -O-SO2-(C4-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-CO-O-Ar in which Ar is optionally substituted phenyl, -O-SO2-(C4-C6 alkyl), -F, -Cl, or -Br; n is an integer from 3 to 8; R3 and R4 each are independently C1-C4 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino; with the proviso that when n is 3, then neither R1 nor R2 can be -O-SO2-(C4-C6 alkyl); or a pharmaceutically acceptable salt or solvate thereof.