Cytokine production inhibitors, triazepine compounds, and intermediates thereof

摘要

The present invention relates to a cytokine production inhibitor comprising a compound of the formula ÄIÜ wherein R<1> is aryl or heteroaryl; B is a group of the formula (a) or (b) wherein R<2> is hydrogen atom, hydroxy, halogen atom and the like, R<4> is hydrogen atom or halogen atom, or R<2> and R<4> in combination form carbonyl; R<3> is lower alkoxy, cycloalkyl, aryl, heteroaryl, -X-Y and the like, wherein X is -(CH2)m-, -CO-, -COCH2-, -NHCH2-, -CH2NH-, -OCH2- and the like, Y is halogen atom, cycloalkyl, aryl or heteroaryl; R<51> is -NHCONHR<57> and the like; R<52> is hydrogen atom or - COOR<53>; A is benzene ring or thiophene ring, novel triazepine compound and intermediates for the production of those triazepine compounds. The compounds of the formula ÄIÜ suppress production of cytokine such as IL-6, TNF- alpha , IL-8, IFN gamma , IL-2, GM-CSF and the like, and are useful as cytokine production inhibitors or antiinflammatory drugs.