| 摘要 |
A system and method for preservation and transport of a donor heart are provided, which includes features for improving the refreshment of the myocardium and for removing toxic catabolites, thereby lengthening the available time for effective transport. The invention utilizes a housing with a perfusion subsystem for retrogradely perfusing the heart, and a subsystem for maintaining the heart in a moderate hypothermic state, preferably at about 10-25 C. A pacemaker is utilized to pace the heart at a below normal rate, preferably in the range of 2-40 bpm, and more preferably 15-30 bpm, so as to continuously squeeze out catabolites and refresh the myocardium with the perfusion fluid. The system can be portable, where the heart can be maintained with or without dialysis; when the apparatus is not being transported, it utilizes power line energy and is adapted to provide dialysis. |
