| 摘要 |
PCT No. PCT/GB97/01547 Sec. 371 Date Feb. 5, 1998 Sec. 102(e) Date Feb. 5, 1998 PCT Filed Jun. 6, 1997 PCT Pub. No. WO97/46508 PCT Pub. Date Dec. 11, 1997The use of polar organic solvent as the solvent in the direct fluorination, to make an alpha -fluoroketone, of an enol ester or enol trialkylsilyl ether of a compound containing a tautomerisable ketone group, the solvent being relatively inert to fluorine and one in which the enol ester or enol trialkylsilyl ether is relatively stable to hydrolysis. Preferably the solvent is anhydrous, e.g. anhydrous acetonitrile. Alternatively commercial formic acid containing 3% water may be used with a said enol ester. |
