| 摘要 |
A substance or composition for use in a method of treatment of a gram-positive bacterial infection of the human or animal body by the administration of said substance or composition to the human or animal body, said substance or composition comprising a compound of formula (II): in which R<1> and R<4> are the same and each is a halogen atom, a haloalkyl radical or an isopropyl radical, n is 1, 2 or 3 and represents the number of R<1> substituents and of R<4> substituents, R<2> is hydrogen, halogen or haloalkyl, and TMP is a tetramethyl piperidyl radical, with the provisos that (a) when n is 2, R<1>n and R<4>n are not 3,4-dichloro- and (b) when n is 1, R<1> and R<4> are not 4-trifluoromethyl-. The bacterial infection may be one or more of the species selected from Mycobacterium aurum, Mycobacterium tuberculosis, Mycobacterium chelonae, Mycobacterium abscessus, Mycobacterium fortuitus, Streptococcuspneumoniae, Enterococcus sp. and Staphylococcus aureus. The compounds may be administered in effective amounts. Also provided as novel pharmaceutically active compounds are N,5-bis(3-chloro-4-fluorophenyl)-3,5-dihydro-3-[(2',2',6',6'-tetramethyl-4-piperidyl)-imino]-2-phenazinamine and N,5-bis(2-chlorophenyl)-3,5-dihydro-3-[(2',2',6',6'-tetramethyl-4-piperidyl)-imino]-2-phenazinamine. |
