发明名称 |
MATRIX METALLOPROTEINASE INHIBITORS |
摘要 |
Succinic amide derivatives of formula (I), wherein W is a -CO2H or -CONHOH group; R, R1 and R2 are each hydrogen or an organic residue, R3 is the residue of an alpha-aminoacid and R4 is an organic group, are inhibitors of matrix metalloproteinases (MMPs) and of the release of tumor necrosis factor-alpha (TNF) from cells, and are therefore useful in the prevention, control and treatment of diseases in which MMPs or TNF are involved. A process for their preparation and pharmaceutical compositions containing them are also described.
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申请公布号 |
WO9749674(A1) |
申请公布日期 |
1997.12.31 |
申请号 |
WO1997EP03251 |
申请日期 |
1997.06.20 |
申请人 |
PHARMACIA & UPJOHN S.P.A.;ALPEGIANI, MARCO;ABRATE, FRANCESCA;BISSOLINO, PIERLUIGI;PALLADINO, MASSIMILIANO;PERRONE, ETTORE |
发明人 |
ALPEGIANI, MARCO;ABRATE, FRANCESCA;BISSOLINO, PIERLUIGI;PALLADINO, MASSIMILIANO;PERRONE, ETTORE |
分类号 |
C07D295/12;A61K31/16;A61K31/426;C07C237/22;C07C259/06;C07C271/22;C07C311/19;C07D213/38;C07D213/40;C07D213/75;C07D277/20;C07D277/44;C07D295/18;C07D295/22;C07D317/66;C07D487/04;C07D487/08;(IPC1-7):C07C259/06;C07D209/48;C07D217/02;C07D277/28;C07D277/46;C07D285/12;C07D307/66;C07D333/36;A61K31/44;A61K31/40;A61K31/47;A61K31/425;A61K31/335 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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