DERIVATIVES OF CARBOXY GEM-BISPHOSPHONATES WITH ANTITUMOR ACTIVITY, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to conjugates of carboxy gem-bisphosphonic acids with alkylating agents. Such derivatives are endowed with remarkable antitumor activity and with specific activity on bone resorption. The present invention also relates to a process for preparing them and to pharmaceutical compositions containing them.