| 摘要 |
<p>A controlled-release formulation comprising, in combination a therapeutically-effective dosage of drug which melts at low temperature and an additive selected from the group consisting of ethyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylamide, ethylene vinyl acetate copolymer, polymethylmethacrylate, polyhydroxyethyl methacrylate and waxes, and the like, such that the additive and the drug form a homogeneous drug-additive composite with a 92-to-97 percent weight/weight of said drug, wherein said drug is selected from the group consisting of: sodium hydrogen divalproex, ibuprofen, ramipril, dibenzyline, erythrityl tetranitrate, isosorbide dinitrate, methosuximide, ketoprofen, gemfibrozil, paroxetine hydrochloride, and trimipramine maleate.</p> |
