发明名称 |
RECOMBINANT VACCINE FOR DISEASES CAUSED BY ENCAPSULATED ORGANISMS |
摘要 |
Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof sufficient to produce non-capsulated mutants of the organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae genetically modified with a large deletion in chromosomal regions of the DNA which encodes for capsule synthesis is a safe and effective vaccine against swine pleuropneumonia.
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申请公布号 |
CA2258168(A1) |
申请公布日期 |
1997.12.31 |
申请号 |
CA19972258168 |
申请日期 |
1997.06.17 |
申请人 |
VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. |
发明人 |
WARD, CHRISTINE;INZANA, THOMAS J. |
分类号 |
A61K35/74;A61K39/00;A61K39/02;A61K39/085;A61K39/102;A61P31/00;A61P31/04;A61P37/04;A61P43/00;C07K14/285;C12N15/09;C12R1/01;(IPC1-7):A61K39/00;C12N1/36 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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