发明名称 |
Oligonucleotides containing hydroxyl-protecting groups orthogonally removable by reduction |
摘要 |
Hydroxyl-protecting groups orthogonally removable by reduction with a liquid reducing agent are disclosed. The novel hydroxyl-protecting groups are particularly useful in the chemical synthesis of linear and branched oligonucleotide structures, as they are readily removed from the protected molecule with mild reagents such as dithionite. Examples of such hydroxyl-protecting groups include the 2-methylene-9,10-anthraquinone (Maq) carbonate ester and the p-nitrobenzyl carbonate ester.
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申请公布号 |
US5703218(A) |
申请公布日期 |
1997.12.30 |
申请号 |
US19950421798 |
申请日期 |
1995.04.13 |
申请人 |
CHIRON CORPORATION |
发明人 |
URDEA, MICHAEL S.;HORN, THOMAS |
分类号 |
C07H19/073;C07H19/10;C07H21/00;C07H21/04;(IPC1-7):C07H21/00 |
主分类号 |
C07H19/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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