发明名称 |
Nucleic acid encoding helicobacter pylori enolase |
摘要 |
An isolated nucleic acid encoding the Helicobacter pylori recombinase is provided. Also provided is an isolated nucleic acid that hybridizes with the recombinase-encoding nucleic acid under stringent conditions and has at least 70% complementarity with the segment of the nucleic acid of SEQ ID NO:1 to which it hybridizes. Also provided is a mutant strain of H. pylori that does not express a functional recombinase (recA- mutant). An isolated nucleic acid encoding the Helicobacter pylori enolase is provided. Also provided is an isolated nucleic acid that hybridizes with the nucleic acid that encodes a H. pylori recombinase under stringent conditions and has at least 70% complementarity with the segment of the nucleic acid of SEQ ID NO:9 to which it hybridizes. Also provided is a mutant strain of H. pylori that does not express a functional enolase (eno- mutant). A method is provided for immunizing a subject against infection by H. pylori by administering to the subject an immunogenic amount of mutant H. pylori in a carrier for the mutant.
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申请公布号 |
US5703219(A) |
申请公布日期 |
1997.12.30 |
申请号 |
US19950446920 |
申请日期 |
1995.05.22 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
THOMPSON, STUART A.;BLASER, MARTIN J. |
分类号 |
A61K39/00;C07K14/205;C12N1/21;C12N9/00;C12N9/88;(IPC1-7):C07H21/04;C12N15/63 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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