Amyloid precursor proteins and method of using same to assess agents which down-regulate formation of beta -amyloid peptide

摘要

This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a beta -amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of beta -amyloid protein.