摘要 |
Compounds of formula (I): <IMAGE> (I) wherein: R1 is hydrogen or alkyl; R2 is alkylene; R3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N-R4, in which R4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): <IMAGE> <IMAGE> and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.
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申请人 |
SANKYO COMPANY, LIMITED |
发明人 |
YANAGISAWA, HIROAKI;FUJITA, TAKASHI;FUJIMOTO, KOICHI;YOSHIOKA, TAKAO;WADA, KUNIO;OGUCHI, MINORU;FUJIWARA, TOSHIHIKO;HORIKOSHI, HIROYOSHI |