摘要 |
We proposed a novel compound having an activity of PGI2 receptor agonist. A phenoxyacetic acid derivative of the formula <IMAGE> A is -C(R1)=N DIFFERENCE OR2, -CH(R)NH-OR2, -COE, -SO2E, -CH2-NR3-Y, -Z-NR3-CONR4R5, -CH2-OR6, -CO2R6, -CH2-O DIFFERENCE N=CR7R8, -CH2-O-NHCHR7R8, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl; T is alkylene, alkenylene, etc.; D is -CO2R10, -CONR11R12; E is (substitution) amino, hydradino; Y is substituted (thio) carbonyl, substituted sulfonyl; Z is -CH=N-, -CH2NR3-; R1, R3, R10-R13 is each H or alkyl, etc.; R2, R4-R9 is each H, alkyl or alkyl substituted by phenyl or hetero ring, etc. and non-toxic salts thereof, non-toxic acid addition salts thereof, possess an agonistic on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
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