PEPTIDE CONTAINING AMINO ACID SEQUENCE OF FIMBRIAL PROTEIN OF -i(PORPHYROMONAS GINGIVALIS) AND USE THEREOF

摘要

There are provided peptides (each having 5 to 10 amino acid residues) corresponding to fragments derived from the amino acid sequence of the 41 kD subunit protein constituting the fimbriae of Porphyromonas gingivalis, or derivatives thereof, or salts of the peptides or derivatives. Further provided are compositions for diagnosis of periodontal disease containing them, vaccines for prophylaxis of periodontal disease containing part of them, and the oral compositions for prophylaxis or treatment of periodontal disease containing antibodies obtained by immunizing animals with the peptides. Peptides are provided which are lowered in nonspecific reactivity and can be used more safely for the above compositions, compared to the above protein and peptides therefrom having 20 amino acid residues.