| 发明名称 |
PROCESS FOR THE SELECTIVE ALKYLATION OF EPOXY-ALCOHOLS |
| 摘要 |
The hydroxy group of an epoxy-alcohol is selectively alkylated, without affecting the epoxy group, by reaction with an alkylating agent in the presence of a solvent and a strong base. As an example, Betaxolol (4) can be prepared according to scheme (1).
|
| 申请公布号 |
CA2257362(A1) |
申请公布日期 |
1997.12.24 |
| 申请号 |
CA19972257362 |
申请日期 |
1997.06.18 |
| 申请人 |
ABBOTT LABORATORIES |
发明人 |
WANG, XIU C.;BHATIA, ASHOK V.;LIU, LUPING |
| 分类号 |
C07C213/04;C07D301/00;C07D303/22;C07D303/24;(IPC1-7):C07C217/34 |
主分类号 |
C07C213/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
