发明名称 |
TIE-2 RECEPTOR LIGANDS (TIE LIGAND-3; TIE LIGAND-4) AND THEIR USES |
摘要 |
The present invention provides for an isolated nucleic acid molecule encoding a member of the TIE ligand family. The present invention also provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptor body which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
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申请公布号 |
CA2258526(A1) |
申请公布日期 |
1997.12.24 |
申请号 |
CA19972258526 |
申请日期 |
1997.06.19 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
JONES, PAMELA F.;YANCOPOULOS, GEORGE D.;VALENZUELA, DAVID M. |
分类号 |
C12N15/09;A61K38/00;A61K38/18;A61K45/00;A61K51/00;A61P35/00;C07K14/17;C07K14/47;C07K14/515;C07K14/71;C07K14/745;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/85;C12P21/02;C12P21/08;(IPC1-7):C12N15/18;A61K51/08;C07K16/22;A61K39/395;C07K14/475;A61K47/48 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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