摘要 |
A series of compounds for blocking calcium activated potassium channels in rat sympathetic neurones and other mammalian cells, and a method for producing them. These compounds with general formulae (I) and (II), where A and B are spacing groups of 3 to 15 carbon atoms Q<-> is the conjugate base of an acid, R<1> and R<4> are for example (a), R<2> and R<3> are for example H, and X is for example NH, exhibit a high potency and are expected to show selectivity between different channel types. The compounds may be useful in the treatment of a number of disorders that are associated with the activity of calcium activated potassium channels, e.g. myotonic muscular dystrophy, gastrointestinal dysmotilities, memory disorders, cancers, narcolepsy and ethanol-induced narcosis. The compounds may also be useful as antibacterial agents.
|
申请人 |
UNIVERSITY COLLEGE LONDON;CAMPOS-ROSA, JOAQUIN;DUNN, PHILIP, MICHAEL;GALANAKIS, DIMITRIOS;GANELLIN, CHARON, ROBIN;JENKINSON, DONALD, HUGH;YANG, DONGLAI;CHEN, JIANQING |
发明人 |
CAMPOS-ROSA, JOAQUIN;DUNN, PHILIP, MICHAEL;GALANAKIS, DIMITRIOS;GANELLIN, CHARON, ROBIN;JENKINSON, DONALD, HUGH;YANG, DONGLAI;CHEN, JIANQING |