| 摘要 |
<p>The invention discloses a bisubstrate analogue effective at inhibiting pyridine nucleotide-dependent enzyme(s). Additionally, disclosed is a method for manufacture of said binding substrate analogue and a complex and drug relating to same. The analogue comprises Diazaborine or part thereof for use in the rational design of bisubstrate enzyme inhibitors which exploit binding energy so as to produce an effective inihibitor, thereby reducing the size of the component of the drug that mimics the substrate. Thus, a compound is produced which is more difficult for an organism to generate resistance against without also compromising the ability of its enzyme to function effectively.</p> |
