4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES AND ANALOGS AS ANTIVIRAL AGENTS

摘要

Herpesvirus protease inhibitor 4H-3,1-benzoxazin-4-one, 4H-thieno[3,2-d][1,3]oxazin-4-one, or 4H-thieno[2,3-d][1,3]oxazin-4-one; derivatives which are 2-substituted by C(XY)-R1, C(XY)-CH2-R1, C(XY)-C2H4-R1, or CX=CY-R1 wherein one of X and Y is hydrogen or halo or an alkyl substituent and the other is hydrogen or an alkyl substituent, and R1 is aryl or heteroaryl substituted by ZR4 wherein Z is CO, NRxCO, NRxCOCO, NRxCOCH2, or NRxSO2 wherein Rx is hydrogen or alkyl and R4 is aryl or heteroaryl.