PYRROLO[1,2-A]PYRAZINE-1,4-DIONE SERINE PROTEASE INHIBITORS

摘要

This invention relates to pyrrolo[1,2-a]pyrazine-1,4-diones of general formula (I), wherein B is carbonyl or methylene, R<2>, R<4>, R<5>, and R<6> are hydrogen, alkyl, or substituted alkyl, A is a basic group, and Q is hydrogen or a keto heterocycle group. The compounds are inhibitors of serine proteases, typically thrombin, Factor Xa, and Factor VIIa, and are useful for treating and preventing thrombotic disorders.