发明名称 |
Finderons and methods of their preparation and use |
摘要 |
Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.
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申请公布号 |
US5700923(A) |
申请公布日期 |
1997.12.23 |
申请号 |
US19940315287 |
申请日期 |
1994.09.29 |
申请人 |
HYBRIDON, INC. |
发明人 |
GOODCHILD, JOHN;LEONARD, THOMAS E. |
分类号 |
A61K38/00;A61K48/00;C12N15/113;(IPC1-7):C07H21/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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