| 摘要 |
Described herein are D4 receptor-selective compounds of the general formula: <IMAGE> wherein X1 is selected from CH2, NH, O and S; X2+E,uns - - +EE is selected from CH=, CH213 , and N=; R1 to R8 are each independently selected from H, C1-4alkyl, halo, cyano, nitro and halo-substituted C1-4alkyl and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.
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