发明名称 |
Stereoisomerberigelse af 2-amino-3-hydroxy-3-phenyl-propion-syrer |
摘要 |
<p>Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.</p> |
申请公布号 |
DK0507153(T3) |
申请公布日期 |
1997.12.22 |
申请号 |
DK19920104752T |
申请日期 |
1992.03.19 |
申请人 |
CELGENE CORPORATION |
发明人 |
STIRLING, DAVID I.;ZEITLIN, ANDREW L.;RAJU, MUPPALA S. |
分类号 |
C07C227/04;C07C315/06;C07C317/48;C07C319/28;C07C323/63;C12P7/24;C12P11/00;C12P13/04;C12P41/00;(IPC1-7):C12P41/00;C07C317/00;C07C315/00 |
主分类号 |
C07C227/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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