| 发明名称 |
TREATMENT OF PROTEIN KINASE C-RELATED DISEASES BY GENE THERAPY |
| 摘要 |
New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha . Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C alpha . Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC alpha . Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC alpha are also disclosed. |
| 申请公布号 |
NZ269653(A) |
申请公布日期 |
1997.12.19 |
| 申请号 |
NZ19940269653 |
申请日期 |
1994.07.08 |
| 申请人 |
ISIS PHARMACEUTICALS INC |
发明人 |
BENNETT, C FRANK;BOGGS, RUSSELL T;DEAN, NICHOLAS, M |
| 分类号 |
C12N15/09;A61K31/7088;A61K31/711;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P29/00;A61P35/00;A61P43/00;C07H21/00;C07H21/04;C07K14/705;C12N5/10;C12N9/12;C12N15/113;C12Q1/48;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/573;G01N33/68;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
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