METHODS AND COMPOSITIONS FOR THE USE OF APURINIC/APYRIMIDINIC ENDONUCLEASES
摘要
Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.
申请公布号
WO9747971(A1)
申请公布日期
1997.12.18
申请号
WO1997US10078
申请日期
1997.06.11
申请人
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE;KELLEY, MARK, R.;DUGUID, JOHN, R.;EBLE, JOHN, N.