发明名称 |
MEDICINAL AEROSOL FORMULATIONS OF FORMOTEROL |
摘要 |
A pharmaceutical suspension formulation suitable for aerosol administration having from 0.0025 to 0.1 % w/w of micronized Formoterol, or an acid addition salt thereof, from 0.1 to 5.0 % w/w ethanol, HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a, and optionally a surfactant other than a monoacetylated or diacetylated monoglyceride, the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.
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申请公布号 |
CA2257841(A1) |
申请公布日期 |
1997.12.18 |
申请号 |
CA19972257841 |
申请日期 |
1997.06.02 |
申请人 |
MINNESOTA MINING AND MANUFACTURING COMPANY |
发明人 |
OLIVER, MARTIN J.;PALING, SIMON G.;JAISWAL, SUKHBINDER K.;JINKS, PHILIP A. |
分类号 |
A61K9/12;A61K9/00;A61K31/167;(IPC1-7):A61K31/16;A61K9/72 |
主分类号 |
A61K9/12 |
代理机构 |
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