| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new protein, having a specific amino acid sequence and capable of manifesting activities of calpain, etc., which is a calcium-dependent neutral protease and its gene useful for prevention, treatment, etc., of cancer, cerebral apoplexy, cerebral infarction, Alzheimer diseases, etc. SOLUTION: This new protein (salt) has the same or substantially same amino acid sequence as that represented by the formula and is capable of manifesting activities of calpain, etc., which is a calcium-dependent neutral protease. A DNA capable of coding the protein is useful as a therapeutic, a preventing agent, etc., for diseases such as cancer, cerebral apoplexy, cerebral infarction, subarachnoidal hemorrhage, Alzheimer disease, muscular dystrophy, cataract, ischemic cardiopathy, arteriosclerosis, arthritis or collagen diseases. The protein is obtained by finding a cDNA having a new base sequence from a cDNA library derived from a human leukocyte, cloning the resultant cDNA, integrating the cloned cDNA into a vector and expressing the DNA in a host cell. |
