| 摘要 |
PROBLEM TO BE SOLVED: To obtain a medicine composition capable of exhibiting excellent effects, reducing a dose and alleviating adverse effect, comprising a compound having angiotensin II antagonism and a compound having an action mechanism except that of angiotensin II antagonism. SOLUTION: This medicine is obtained by combining a compound of the formula (R<1> is H or a substitutable hydrocarbon residue; R<2> is carboxyl which can be esterified; R<3> is an anion forming group, etc.; X is phenylene directly bonded to phenylene or bonded through phenylene; (n) is 1 or 2; the ring A is as shown for R<2> or a benzene ring which may be substituted; Y is a direct bond, O, etc.) having angiotensin II antagonism or its salt as an active ingredient with at least one of a compound having enhancing action on insulin sensitivity, a compound having improving action on hyperglycemia of diabetic after meal, an indane derivative having inhibitory action on an enzyme capable of converting angiotensin, a pyridine derivative having inhibitory action on HMG- GoA reductase and their salts. The medicine is effective useful for arterial hypertension as a complication of arteriosclerosis and hypertension. |
