发明名称 |
Methods and compositions for inhibiting production of replication competent virus |
摘要 |
The present invention provides methods and compositions for inhibiting the production of replication competent virus. The invention comprises nucleic acid cassettes encoding a non-biologically active inhibitory molecule which are incorporated into packaging cells and recombinant vector constructs. Upon recombination between various vector construct contained within the producer cell, a biologically active molecule is produced which kills the cell, thereby inhibiting production of replication competent virus.
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申请公布号 |
US5698446(A) |
申请公布日期 |
1997.12.16 |
申请号 |
US19940305699 |
申请日期 |
1994.09.07 |
申请人 |
CHIRON CORPORATION |
发明人 |
KLUMP, WOLFGANG M.;JOLLY, DOUGLAS J. |
分类号 |
C12N15/09;C12N5/10;C12N7/00;C12N7/01;C12N15/867;C12R1/92;(IPC1-7):C12N5/10;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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