| 摘要 |
<p>Drug complexes wherein a carboxy (C1-4)alkyldextran polyalcohol, which has been treated under such conditions as to allow the substantially complete formation of the polyalcohol, is bonded to the residue of a medicinal compound such as an antitumor agent via a spacer consisting of one amino acid or a spacer consisting of two to eight amino acids bonded to each other via peptide bonds. The complexes are excellent in the tumor site selectivity and thus can exhibit a high antitumor effect with relieved expression of toxicity.</p> |
