PROCESS FOR PRODUCING DRUG COMPLEXES

摘要

A process for producing drug complexes wherein a carboxylated polysaccharide derivative is bonded to a medicinal compound residue via a spacer consisting of an amino acid or a spacer consisting of two to eight amino acids bonded to each other via peptide bonds, or drug complexes wherein a carboxylated polysaccharide derivative is bonded to a medicinal compound residue via no spacer, which is characterized by reacting in a nonaqueous system an organic amine salt of the carboxylated polysaccharide derivative with the medicinal compound or the spacer bonded thereto. Thus, the reaction between the carboxylated polysaccharide derivative and the medicinal compound bonded to the spacer, etc., can be effected to achieve a high yield and side reactions can be inhibited in the case where, for example, the medicinal compound is one having a lactone ring.