| 发明名称 |
TUMOR NECROSIS FACTOR-RELATED POLYPEPTIDE |
| 摘要 |
A novel member of the tumor necrosis factor (TNF) family was identified and observed to be involved in inflammation and necrosis, especially of the liver, myelopoiesis and bone resorption. The polypeptide is termed AGP-1. Nucleic acid sequences, vectors and host cells for the expression of AGP-1 are disclosed. Methods for identifying antagonists of AGP-1, pharmaceutical compositions comprising AGP-1 and methods of treatment using AGP-1 and AGP-1 antagonists are also disclosed.
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| 申请公布号 |
CA2256464(A1) |
申请公布日期 |
1997.12.11 |
| 申请号 |
CA19972256464 |
申请日期 |
1997.06.06 |
| 申请人 |
AMGEN INC. |
发明人 |
JOHNSON, MERRIE JO;SIMONET, WILLIAM SCOTT;DANILENKO, DIMITRY MICHAEL |
| 分类号 |
A01K67/027;A61K38/00;A61K45/00;A61K48/00;A61P7/00;A61P19/00;A61P29/00;C07K14/525;C07K14/705;C07K16/24;C12N1/21;C12N15/09;C12N15/19;C12N15/85;C12P21/08;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/577;(IPC1-7):C12N15/19;C07K17/08;A61K38/19;C07K14/52;A61K31/70 |
主分类号 |
A01K67/027 |
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