发明名称 |
METABOTROPIC GABA[B] RECEPTORS, RECEPTOR-SPECIFIC LIGANDS AND THEIR USES |
摘要 |
The present invention provides purified GABAB receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAB receptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAB receptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAB receptor family isolated by such methods. Furthermore, the invention relates to the use of GABAB receptors and receptor proteins and cells transformed with a gene encoding a GABAB receptor protein in a method for identifying and characterising compounds which modulate the activity of the GABAB receptor, such as GABAB receptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.
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申请公布号 |
CA2254862(A1) |
申请公布日期 |
1997.12.11 |
申请号 |
CA19972254862 |
申请日期 |
1997.03.19 |
申请人 |
NOVARTIS AG |
发明人 |
FR STL, WOLFGANG;BITTIGER, HELMUT;BETTLER, BERNHARD;MICKEL, STUART JOHN;KAUPMANN, KLEMENS |
分类号 |
A01K67/027;A61K38/00;C07F9/30;C07K14/705;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/08;C12Q1/68;G01N33/15;G01N33/50;(IPC1-7):C12N15/12;C07H21/04;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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