| 摘要 |
The use of a compound of formula (I) in which: R<1> and R<2> are the same or different and each represents a hydrogen atom or a C1 - C5 alkyl group; R<3> represents a hydrogen atom, a C1 - C6 aliphatic acyl group, a (C5 - C7 cycloalkane) carbonyl group, an aromatic acyl group which is a benzoyl or naphthoyl group optionally with one or more nitro, amino, alkylamino, dialkylamino, alkoxy, halo, alkyl or hydroxy substituents, a heterocyclic acyl group having one or more oxygen, sulphur or nitrogen hetero atoms and with 4 to 7 ring atoms, an optionally halo-substituted phenylacetyl or phenylpropionyl group, a cinnamoyl group, a (C1 - C6 alkoxy) carbonyl group or a benzoyloxycarbonyl group; R<4> and R<5> are the same or different and each represents a hydrogen atom, a C1 - C5 alkyl group or a C1 - C5 alkoxy group, or R<4> and R<5> together represent a C1 - C4 alkylenedioxy group; n is 1, 2 or 3; W represents the -CH2, > CO or > CH-OR<6> group (in which R<6> represents any one of the atoms or groups defined for R<3> and may by the same as or different from R<3>); and Y and Z are the same or different and each represents an oxygen atom or an imino (=NH) group; or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the amelioration of inappropriate endothelial cell activation.
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