发明名称 |
A METHOD FOR ENHANCING LONG-TERM MEMORY IN A SUBJECT AND USES THEREOF |
摘要 |
The present invention provides for a method to enhance longterm memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.
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申请公布号 |
WO9746257(A1) |
申请公布日期 |
1997.12.11 |
申请号 |
WO1997US09438 |
申请日期 |
1997.06.03 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF |
发明人 |
BARTSCH, DUSAN;KANDEL, ERIC, R.;GHIRARDI, MIRELLA |
分类号 |
A61K45/00;A61K31/00;A61K38/00;A61K39/395;A61K48/00;A61P25/00;A61P25/16;A61P25/28;A61P43/00;C07K14/47;C07K16/18;(IPC1-7):A61K39/395;A61K39/40;A61K39/42 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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